Seminar: Tools and Strategies for Non-Animal Safety Assessment

The seminar will focus on the following topics:

Introduction/NAMs

• Scope of available NAMs
• Regulatory context, IATA, NGRA overview
• Inhalation risk assessment case study
• Q&A

State of the Science

• Skin/eye methods
• Skin sensitization, incl. risk assessment methods
• Photosafety assessment
• Genetic toxicity incl. Toxtracker
• Break for Q&A included

EC3 derivation workshop

• This participatory exercise will walk participants through the use of in vitro data to derive a Point of Departure (predicted LLNA EC3) which can be used to evaluate the skin sensitization potency as well as downstream use for risk assessment.

Next-Generation Risk Assessment case study workshop

• Participants will work in groups to analyze data underlying an NGRA risk assessment evaluating systemic toxicity for a sunscreen ingredient, including systemic and internal exposure, bioactivity, IVIVE, and setting a point of departure. Small group and plenary discussions will follow to discuss how to develop confidence in making safety decisions with non-animal approaches.